Cytodigm, Inc., a preclinical-stage biotech company based in Natick, MA, is advancing its proprietary cell-targeted lipid-based nanoparticles (LNPs) to develop genetic medicines that address numerous unmet medical needs. We are currently seeking a highly motivated, creative, and diligent co-op or intern for a lipid nanoparticle formulation internship to support our R&D programs. The ideal candidate will learn to assist with the preparation and characterization of our LNPs for preclinical studies. This lipid nanoparticle formulation internship provides hands-on experience working with nucleic acid delivery systems supporting genetic medicine research.
– Learn to operate the company’s equipment and setups for preparing LNPs encapsulating various nucleic acid payloads, including DNA, mRNA, siRNA, and oligonucleotides.
– Use the company’s proprietary process to attach targeting ligands to the surface of LNPs.
– Learn and conduct characterization of LNPs, assessing particle size, zeta potential, cargo loading, encapsulation efficiency, and more.
– Perform cell assays to evaluate the in vitro performance of the company’s LNPs in different cell types.
– Collaborate with Cytodigm’s scientists to scale up proprietary LNP formulations for in vitro and in vivo studies.
– Maintain accurate and detailed records of experiments.
– Collect data, including information from CROs, and generate study reports.
– Present and communicate scientific results to the internal team.
– Candidates must be pursuing an undergraduate or graduate degree in chemistry, biochemistry, chemical engineering, biomedical engineering, biology, or a related field.
– 1-3 years of industrial or academic experience in an R&D setting is preferred.
– Knowledge and hands-on laboratory experience with lipid-based nanoparticles, such as liposomes and LNPs, is advantageous.
– Ability to independently design, implement, troubleshoot, and analyze experiments to achieve desired results is preferred.
– A solid understanding of nucleic acid biology is required.
– Strong oral and written communication skills, with proficiency in Microsoft Office applications, are essential.
Please email your resume to hr@cytodigm.com
